A dissolution test is a means of identifying and proving the availability of active drug materials in their delivered form. A dissolution test simulates the availability of active substance and allows the prediction of the time for complete release of the material from the dosage form.
Tablet dissolution testing is one of the most important tests during development and manufacturing of solid dosage forms, transdermals, ointments and creams, suppositories etc. Nearly all international pharmacopoeias describe a dissolution test instrument, in which at least 6 samples should be tested. The test vessel design, stirring speed range, temperature range and accuracy, stirrer design and relevant tolerances are clearly specified.
- All Pharma Test instruments are fully USP <711/724> and EP <2.9.3/4> compliant
- Number of stirred position from 6 to 12
- Low head and high head instruments available
- All dissolution baths are prepared for dissolution automation
- MonoShaft™ system to avoid re-adjustment of immersion depth
- Vibration absorber to avoid vibration transfer into the USP/EP vessels
- Ultra-fast heating system with excellent temperature stability
Standalone Dissolution Testing includes: – PTWS 1220, PTWS 820D, PTWS D620, PTWS 4000, PTWS 120S/D, DT 70.
The PTWS 1220 is a 6 + 6 stirred position, single drive tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>, having 2 extra beakers to take media refilling and reference standard media. The PTWS1220 is the ideal choice for Bio-Waiver studies and Dissolution Method Development.
Features:
- 6 front line and 6 back line vessels for easy access in manual operation
- 2 extra vessels for refilling or standard media
- Individual 3-point vessel cantering. Excellent access to all vessels
- Screen information offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time)
- Staggered start feature for convenient manual sampling
The PTWS D620 is Dual-Drive 6 + 6 stirred position tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>, having 2 extra beakers to take media refilling and reference standard media. The instrument has also two additional vessels (approx. 250 ml) for media refilling and reference standard media.
Features:
- 12 stirred positions, separate speed control for front (6) and back (6) line stirrers
- File up a nearly unlimited number of different test descriptions (methods)
- Drainage tap to empty the bath
- Method management and user administration User access control, password expiry control
- Traffic Light optical information on display shows the instrument status by different colors (green = ready to use, yellow = preparing to use, red = error encountered)
- Interfaces – USB port for to use the memory stick, RS232 port for external control; I/O port for remote control of external instruments in automated applications
The PTWS 820D is an 8 position, single drive compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB and Japanese Pharmacopeia section <15>.
Features:
- Modular design to minimize bench space requirements
- 3-point individual vessel centering system , Excellent access to all vessels
- Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
- MonoShaft™ system to avoid re-adjustment of immersion depth
- Staggered stirrer start feature for convenient manual sampling
- Water diffuser for even temperature distribution
- Spring loaded pump assembly to eliminate vibration transfer
- Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
- Excellent stirrer shaft verticality inside the vessels due to central position of lift columns and drive head assembly
- Easy removal of the water bath from of the frame work for cleaning and maintenance work
The PTWS 620 is a 6 + 2 position, single drive tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>.
Features:
- 8 (6+2) stirred positions
- 6 front line vessels for easy access in manual operation
- Screen information offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time)
- Water diffuser for even temperature distribution
- Vibration absorber to avoid vibration transfer into the USP/EP vessels
- Spring loaded pump assembly to eliminate vibration transfer to the frame work
- MonoShaft™ system to avoid re-adjustment of immersion depth
PTWS 4000 is the only tablet dissolution testing instrument available to support vessel sizes up to 4 liters for pool test applications of highly concentrated samples. PTWS 4000 contains six stirred glass vessels with a volume of approx. 4 litters each in a single row in the front side of the instrument
Features:
- The only tablet dissolution testing instrument supporting 4 liter vessels. Optional 1/2 liter vessels also can be used by adapter.
- Six vessels in front offer optimal view of the samples
- Easy access to all vessels
- Monoshaft™ system to avoid re-adjustment of immersion depth
- Clear-view Plexiglass water bath for excellent visibility
- TWS trafic light warning system monitors critical parameters
- GMP compliant stainless steel housing
The PTWS 120S is a 6 position, multiple drive, compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the BP, DAB and Japanese Pharmacopeia section <15>.
Features:
- Individual stirrer speed control for method development and profiling tests
- Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
- Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
- Ultra-fast heating system due to newly designed heat exchanger
- Modular design to minimize bench space requirements
- Individual vessel centering, Excellent access to all vessels
The PTWS 120D is a 6 position, multiple drive, compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the BP, DAB and Japanese Pharmacopeia section <15>.
Features:
- Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
- Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
- 6 single drive motorized stirred positions
- Centrally located motorized lift drive to raise and lower the drive head
- Vessel low evaporation sealing covers
- USB port for remote control of the PTWS 120D
The PT-DT70 is the low head FLIP-BACK Dissolution Tester from Pharma Test. It provides a space saving, low cost entry into dissolution testing. Whether for a new laboratory or to meet tough budget requirements, the PT-DT70 offers a lot of instrument for a comparatively modest cost.
Features:
- 7 test stations = 1 additional unstirred vessel for blank or reference medium.
- 4 + 3 format for USA FDA friendly application.
- Internal Buzzer, programmable sampling information
- Housing made from stainless steel, top cover PP moulded
- Fully adjustable and fully regulated paddle speed selection from 25 to 250 rpm.
- Built in heater with microprocessor temperature control, over the range 25 to 45OC. Less than 0.3°C temperature deviation within the entire water bath