Ready for your biomolecular analysis

For laboratories that know biomolecules sometimes need to work harder to move through a chromatographic instrument, the biocompatible ACQUITY UPLC® H-Class Bio System is ready.

Engineered with a bio-inert flow path made of non-stainless-steel materials, the ACQUITY UPLC H-Class Bio System keeps large molecules intact and on the move, for better sample recovery and no carryover, whether the chromatographic mode you’re using is reversed phase (RP), ion exchange (IEX), size exclusion (SEC), or hydrophilic interaction (HILIC).

The ease of reversed phase meets the power of normal phase.

With the ACQUITY UPC2 System, the orthogonal capability of normal-phase LC has been elevated to a mainstream technique: Convergence Chromatography.

Features:

• The chromatographic principles and selectivity of normal-phase LC
• The ease-of-use and method development simplicity of reversed-phase LC
• The use of gradients across the widest polarity range
• Chiral and achiral separations in one system, with unequaled speed and confidence

Bringing ease-of-use to normal-phase LC

By providing the ability to precisely vary mobile phase strength, pressure, and temperature, the Waters ACQUITY UPC2 System gives scientists the power to better control the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diasteriomeric mixtures.

The world’s first convergence chromatography system

Unique in its capabilities, the pioneering ACQUITY UPC2 System delivers what the rest of the industry never could – a system, based on the principles of normal-phase LC, with the ease-of-use of reversed-phase LC, and purposefully built for analytical performance, placing convergence chromatography atop the list of separations tools in the kit of all analytical chemists.

PDA detection for spectral exposure optimization

The ACQUITY UPLC Photodiode Array (PDA) e λ Detector allows a laboratory to detect and quantify lower concentrations of sample analytes and compare spectra across a broad wavelength range.

Features:

• Wavelength range of 190 to 800 nm for a greater diversity of applications
• Quantitate up to 2.0 AU without compromising linearity
• Fixed optical resolution provides high-quality spectral resolution

Ground-breaking technology takes PDA detection to the next level

The ACQUITY UPLC PDA Detector provides highly sensitive spectral information to aid in making better decisions about an analysis.

Features:

• Spectral analysis from 190 to 500nm
• Superior linear range with constant optical bandpass
• Definitive compound identification and co-elution detection with simultaneous 2D and 3D operation

Unrivaled sensitivity and selectivity in UPLC detection

he ACQUITY UPLC Fluorescence (FLR) Detector is a high-sensitivity, multi-channel fluorescence detector optimized for UPLC/UHPLC separations.

Features:

• Innovative flow cell design, low-noise electronics, and support for high-speed data
• AAdvanced optical design reduces light scatter, allowing for maximum light throughput and optimum signal-to-noise performance
• Low-volume flow cell increases opportunity for light absorption and enhances sensitivity

Low-dispersion, refractive index detection for UPLC and APC

Features:

• Universal detection of analytes without a UV chromophore that are separated by isocratic analysis
• Full compatibility with a wide range of challenging solvents
• Low-dispersion characteristics for narrow UPLC and APC peaks
• Low baseline drift due to a thermally isolated optics bench and highly efficient temperature equilibration of the incoming eluent

See more of what you need, and see it faster with ELSD for UPLC

Increase peak confidence across a wide application range with optimal UPLC/ELS (ELSD) performance in a small footprint.

Features:

• Collect more information by monitoring compounds that have poor to no UV/Vis response
• Engineered for a variety of sample sizes, especially high throughput or open access environments
• Designed to provide a convenient stackable design, easy maintenance, and long lamp lifetimes