Isocratic HPLC

515 Based Pump

The 515 HPLC pump is a programmable, free-standing HPLC pump available in isocratic, gradient, and semi-preparative configurations:


  • Precise stepper motor control (48 steps/µL resolution) of dual reciprocating pistons
  • Non-circular drive gears provide smooth, uniform eluent delivery
  • User-programmable flow rate calibration and compressibility compensation factors ensure straightforward pump operation qualification
  • Tests to retention time variations of less than 0.1% for highly reproducible peak performance
  • Easy-to-read display and keypad for error-free programming
  • Automatic purging and flow calibration
2707 Autosampler

The 2707 Autosampler is a versatile, compact sample management system that makes highly precise and reproducible injections of samples into your LC or LC/MS system. It is ideally suited for laboratories where reduced carryover, maximized repeatability, high accuracy, and application flexibility are of concern.


  • Compact design yet easily serviceable
  • High-resolution syringe control for high-precision injections
  • Interchangeable fixed-volume sample loops
  • Variable-volume partial-loop injection capability
  • Optional sample cooling for consistent results
  • Pressure-assisted sample aspiration injection capability
  • Use of plates or vials, alone or in combination, for varied sampling formats
  • Empower™ Software control

Binary Gradient HPLC

1500 Series HPLC Pump / 1515 Isocratic HPLC Pump

The 1515 Isocratic HPLC Pump is an isocratic pump that offers the same performance as the 1525 Binary HPLC Pump. It features and integrated, high-pressure binary pump with on-board pulse dampening and efficient mixing. Its pulse-free solvent flow with analytical to semi-preparative flow rates are well suited for high sensitivity detectors.

Designed for use with 2 to 4.6 mm I.D. columns in routine HPLC applications, the pump has a programmable flow-rate range of 0.00 to 10.00 mL/min in 0.01 mL increments.

1500 Series HPLC Pump / 1525 Binary HPLC Pump

The 1525 and 1525 with EF heads are integrated, high-pressure, binary HPLC pumps that feature on-board pulse dampening and efficient mixing. Their pulse-free solvent flow, from analytical to semi-preparative flow rates, makes them ideal for use with highly sensitive detectors.

Designed for use with 2 to 4.6 mm I.D. columns in routine LC and LC/MS applications, these pumps have a programmable flow-rate range of 0.00 to 10.00 mL/min in 0.01 mL increments.

Breeze 2 HPLC

The Breeze™ 2 HPLC System delivers technology and performance in an affordable, compact, and user-friendly system platform. Complete with software, pump, detector and injector, the system comes pre-configured for different levels of HPLC operational needs.


  • A completely flexible system that is customizable for any laboratory with quality HPLC components options: binary or isocratic pump, automated or manual injector, UV/Vis, refractive index, multi-? fluorescence, evaporative light scattering, or photodiode array detector
  • Intuitive interface with Breeze 2 Software that allows for easy set-up, operation, and minimal training

Quaternary Gradient HPLC

Alliance HPLC System

HPLC has never looked better…


  • Time-tested, flexible, and reliable workhorse for your HPLC separations.
  • New industrial design, exemplifying Waters’ continued commitment to our industry-trusted HPLC line.
  • Bridge the gap between HPLC and UPLC performance with CORTECS 2.7 µm Columns.
  • Integrated solvent and sample management to ensure consistent system-to-system performance and high reproducibility.
  • Delivers mass spectral data with the ACQUITY QDa Detector.
  • Integrated HPLC System.
  • One switch button to start the machine
ACQUITY Arc System

HPLC and UHPLC method compatibility at the flip of a switch

The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays.


  • True plug-and-play method compatibility and the ability to switch between HPLC and UHPLC separations at the flip of a switch with Arc Multi-flow path Technology
  • Get mass detection, without changing the way you work, with the ACQUITY QDa Detector
  • Deploy the benefits of 2.x ?m particle columns to boost the chromatographic performance of your methods
  • On-demand mobile phase creation with Auto Blend Plus Technology, eliminating the cumbersome and error-prone approach of manual preparation

HPLC Detector


Separating Beyond Question – Bringing the Power of Mass Detection to You Certainty Above All Else – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.


  • Intuitive operation
  • More information from every sample
  • Effortless integration
  • Increased efficiency
  • Resolving complexity

2489 UV/Visible (UV/Vis) Detector for Alliance HPLC Systems

The most sensitive and versatile dual-wavelength absorbance detector available for HPLC Whether performing routine UV-based applications or pushing the limits of detection with low-level impurity analyses, the Waters 2489 UV/Visible (UV/Vis) Detector is the best detection choice for performance, reliability, and usability.


  • Linear range of 2.5 AU enables the identification and quantitation of both major and minor components in the same run.
  • Ability to monitor absorbance at two user-selectable wavelengths, resulting in more analyte information per run and increased productivity
  • Lamp serial numbers, hours, and number ignition tracking provides confidence for optimal system usage

2998 Photodiode Array (PDA) Detector for Alliance HPLC Systems

Advanced optical detection for HPLC analyses The 2998 PDA Detector’s uniquely integrated software and optics innovations make it the ideal detector for any lab application, from compound identification to method development.


  • Enhanced software control provides flexibility for simultaneous 2D and 3D operation with either Empower or MassLynx Software
  • High-quality spectral resolution by operating at a fixed optical resolution of 1.2 nm
  • Capability for determining spectral homogeneity, yielding confidence in method specificity

2414 Refractive Index (RI) Detector for Alliance HPLC Systems

Reliable and repeatable analysis of non-absorbing components The 2414 RI Detector is the ideal solution for the analysis and quantification of components with limited or no UV absorption, such as alcohols, sugars, sacharides, fatty acids and polymers.


  • Improved temperature controls provides faster warm-up times and baseline stability
  • External output necessary to support advanced fraction collection routines
  • Control of external column heater to control columns from 30 – 150 °C for a broad range of applications

2475 Fluorescence (FLR) Detector for Alliance HPLC Systems

The culmination of HPLC sensitivity and selectivity The 2475 FLR Detector helps achieve high-sensitivity, low-dispersion methods with unsurpassed accuracy, maximum uptime, and complete confidence in the analysis.


  • Multiple detection modes – 2D, 3D, and on-the-fly spectral scanning
  • Low-dispersion system solution compatible with a wide range of column dimensions
  • Normalized emission units for better bench-to-bench reproducibility

432 Conductivity Detector

The Waters 432 Conductivity Detector features a multi-electrode flow cell that offers exceptional stability and sensitivity for chemically-suppressed or single-column ion chromatography. With auto zero and auto ranging capabilities, the 432 Detector gives chemists automatic conductivity range selection and the freedom of unattended operation. The 432 Detector can operate stand-alone module or as part of an LC system.


  • High sensitivity and stability due to multi-electrode, temperature-controlled flow cell
  • Patented 5 electrode flow cell design eliminates noise from the background eluent typically seen with 2 electrode flow cell designs
  • Reduced flow path volume for narrow-bore applications
  • Increased operational uptime with self-diagnostics
  • Autorange ensures a precise conductivity base range
  • Integrated leak sensors

2465 Electrochemical Detector for HPLC Systems


  • Multiple detection modes, including direct current, pulsed amperometric, and scanning
  • Easier maintenance with front-mounted flow cell for simple cleaning and assembly
  • Stabilized temperature for better accuracy with the integral flow cell and column heater compartment
  • Faraday-shielded oven with thermal operating stability and reduced noise and drift characteristics
  • Electrode options for a variety of applications

2424 Evaporative Light Scattering (ELS) Detector for Alliance HPLC

Achieve richer analysis

The Waters 2424 ELS (ELS) Detector was designed to provide a critical balance in mind to deliver good sensitivity of semi-volatile components and low peak dispersion.


  • Active nebulizer heating and cooling for method optimization and rapid stabilization
  • 60° scatter angle detection to minimize stray light and optics polarization for long-term optimal sensitivity
  • Optimal energy output for improved bench-to-bench repeatability