UPLC Instruments

Acquity UPLC System

UPLC transforms the expectations of laboratories worldwide

UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is highly robust, dependable, and reproducible.

Features:

  • Work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures
  • Higher flow rates and increased throughput result in superior resolution and sensitivity
  • Eliminate significant time and cost per sample, while improving quality of results
  • Benefit from Waters’ patented sub-2-?m hybrid particle chemistry

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Acquity UPLC-H Class System

Highest resolution of any quaternary LC system
Features:

  • Improve your laboratory’s efficiency by scaling your methods to UPLC Technology
  • Use UPLC’s unmatched resolution to get better characterization of your complex samples
  • Take advantage of tools that simplify and streamline your method development workflow
  • Future-proof your lab by running your existing HPLC and UHPLC methods today and then transitioning to UPLC when you are ready

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Acquity UPLC-I Class System

What separates you from everyone else.
Features:

  • Maximizes peak capacity to enhance MS sensitivity
  • Provides the lowest carryover, complementing MS sensitivity and extending MS linear dynamic range
  • Has been purposefully engineered for the lowest dispersion; with an extended pressure/flow envelope, complex separations can be accelerated without compromising chromatographic fidelity

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Acquity UPLC-M Class System

LET YOUR LC INLET DO THE WORK FOR YOUR NANO- TO MICROSCALE SEPARATIONS
Features:

  • System of choice for sample-limited applications in proteomics and biomarker discovery
  • Higher sensitivity for any MS
  • Maximum amount of data from any sample
  • Less sample preparation volume and cost
  • Reduced solvent consumption
  • Increased dynamic range
  • Flexible configurations for HDX technology, 2D, and UV detection

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Acquity UPLC-H Class Bio

Ready for your biomolecular analysis

For laboratories that know biomolecules sometimes need to work harder to move through a chromatographic instrument, the biocompatible ACQUITY UPLC® H-Class Bio System is ready.

Engineered with a bio-inert flow path made of non-stainless-steel materials, the ACQUITY UPLC H-Class Bio System keeps large molecules intact and on the move, for better sample recovery and no carryover, whether the chromatographic mode you're using is reversed phase (RP), ion exchange (IEX), size exclusion (SEC), or hydrophilic interaction (HILIC).

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Acquity Advanced Polymer Chromatography System

Beyond GPC and SEC size-based chromatography

The ACQUITY Advanced Polymer Chromatography (APC) System is a breakthrough technology that defines the ultimate in size-based chromatographic separations, delivering more information about your polymers faster than ever before. This means better characterization, improved asset utilization, and a superior solution for achieving corporate innovation and sustainability goals .

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Acquity UPC2 System

The ease of reversed phase meets the power of normal phase.

With the ACQUITY UPC2 System, the orthogonal capability of normal-phase LC has been elevated to a mainstream technique: Convergence Chromatography.

Features:

  • The chromatographic principles and selectivity of normal-phase LC
  • The ease-of-use and method development simplicity of reversed-phase LC
  • The use of gradients across the widest polarity range
  • Chiral and achiral separations in one system, with unequaled speed and confidence
Bringing ease-of-use to normal-phase LC

By providing the ability to precisely vary mobile phase strength, pressure, and temperature, the Waters ACQUITY UPC2 System gives scientists the power to better control the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diasteriomeric mixtures.

The world's first convergence chromatography system

Unique in its capabilities, the pioneering ACQUITY UPC2 System delivers what the rest of the industry never could – a system, based on the principles of normal-phase LC, with the ease-of-use of reversed-phase LC, and purposefully built for analytical performance, placing convergence chromatography atop the list of separations tools in the kit of all analytical chemists.

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UPLC Detectors

ACQUITY QDA Detector

Separating Beyond Question – Bringing the Power of Mass Detection to You Certainty Above All Else – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.

Features:

  • Intuitive operation
  • More information from every sample
  • Effortless integration
  • Increased efficiency
  • Resolving complexity

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ACQUITY UPLC TUNABLE UV DETECTOR

UV detection, optimized for UPLC/UHPLC separations

The ACQUITY UPLC TUV Detector provides performance benefits for both routine and complex analyses in pharmaceutical, life science, environmental, agricultural, energy, and petrochemical applications.

Features:

  • Wavelength Range from 190 to 700 nm
  • Linear dynamic range that extends more than 3.5 orders of magnitude
  • Wavelength accuracy of ± 1 nm to ensure precise detection wavelength

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ACQUITY UPLC PDA eλ DETECTOR

PDA detection for spectral exposure optimization

The ACQUITY UPLC Photodiode Array (PDA) e λ Detector allows a laboratory to detect and quantify lower concentrations of sample analytes and compare spectra across a broad wavelength range.

Features:

  • Wavelength range of 190 to 800 nm for a greater diversity of applications
  • Quantitate up to 2.0 AU without compromising linearity
  • Fixed optical resolution provides high-quality spectral resolution

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ACQUITY UPLC PDA DETECTOR

Ground-breaking technology takes PDA detection to the next level

The ACQUITY UPLC PDA Detector provides highly sensitive spectral information to aid in making better decisions about an analysis.

Features:

  • Spectral analysis from 190 to 500nm
  • Superior linear range with constant optical bandpass
  • Definitive compound identification and co-elution detection with simultaneous 2D and 3D operation

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ACQUITY UPLC FLR DETECTOR

Unrivaled sensitivity and selectivity in UPLC detection

he ACQUITY UPLC Fluorescence (FLR) Detector is a high-sensitivity, multi-channel fluorescence detector optimized for UPLC/UHPLC separations.

Features:

  • Innovative flow cell design, low-noise electronics, and support for high-speed data
  • AAdvanced optical design reduces light scatter, allowing for maximum light throughput and optimum signal-to-noise performance
  • Low-volume flow cell increases opportunity for light absorption and enhances sensitivity

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ACQUITY UPLC REFRACTIVE INDEX (RI) DETECTOR

Low-dispersion, refractive index detection for UPLC and APC
Features:

  • Universal detection of analytes without a UV chromophore that are separated by isocratic analysis
  • Full compatibility with a wide range of challenging solvents
  • Low-dispersion characteristics for narrow UPLC and APC peaks
  • Low baseline drift due to a thermally isolated optics bench and highly efficient temperature equilibration of the incoming eluent

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ACQUITY UPLC ELS DETECTOR

See more of what you need, and see it faster with ELSD for UPLC

Increase peak confidence across a wide application range with optimal UPLC/ELS (ELSD) performance in a small footprint.

Features:

  • Collect more information by monitoring compounds that have poor to no UV/Vis response
  • Engineered for a variety of sample sizes, especially high throughput or open access environments
  • Designed to provide a convenient stackable design, easy maintenance, and long lamp lifetimes

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