ENDOSAFE®-PTS™

The Endosafe®-PTS™ is a handheld spectrophotometer that utilizes FDA-licensed disposable cartridges for accurate, convenient endotoxin testing. With test results in just 15 minutes, you can rapidly move forward with your study or the next step in your process.

Features:

The PTS is so easy-to-use, you can run the test in just three simple steps:

  • Enter your sample ID into the system’s memory using the keypad
  • Add your sample to the disposable LAL cartridge pre-filled with all of the reagents needed for the assay
  • Press enter on the key pad

With quantitative endotoxin results available in 15 minutes, you will identify production problems faster, release product more efficiently, and get answers faster than ever before. Product details include

  • System includes the reader and FDA-licensed LAL cartridges
  • The PTS runs on battery power so testing is portable
  • Quantitative results can be downloaded to a central PC for tracking and trending
  • Three levels of sensitivity are available – 0.01, 0.05 and .005 EU/mL – for testing options
  • No microbiology training is required – anyone can run this simple assay


ENDOSAFE®-MCS

Are you testing multiple endotoxin samples at a time and waiting for results? The Endosafe®-MCS system allows users to test multiple samples easily and efficiently and receive results in as little as 15 minutes.

The Endosafe-MCS is a multi-cartridge system that utilizes FDA-licensed disposable cartridges for accurate, convenient endotoxin testing. The MCS is a bench-top test system that runs with your PC and EndoScan-VTM, Charles River’s endotoxin-measuring software. Each cartridge runs independently of the others. With random access, you can run your samples as needed and not wait for a full batch of samples for testing.

Features:

Testing is simple:

  • Enter your sample ID into EndoScan-V
  • Add your sample to the disposable LAL cartridge pre-filled with all of the reagents needed for the assay
  • Click on “start assay”

With quantitative endotoxin results available in 15 minutes, you will identify production problems faster, release product more efficiently, and get answers faster than ever before. Product details:

  • System includes the multi-cartridge reader, EndoScan-V software, and FDA-licensed LAL cartridges
  • Quantitative results can be downloaded to Microtrend software tracking and trending
  • Two levels of sensitivity are available – 0.01 EU/mL and 0.05 EU/mL – for testing options
  • No microbiology training is required – anyone can run this simple assay
  • System qualification and validation support is provided if needed


ENDOSAFE® NEXUS™

The Endosafe® Nexus™ is the first fully automated robotic system designed specifically for endotoxin testing in the central QC lab. Ideal for high-volume water testing or samples that require dilutions, the system utilizes proven innovative LAL cartridge technology a state-of-the-art liquid handling system and simple data management software to test 48 to 60 samples with minimal preparation and supervision.

The system offers the unique opportunity to reduce technician time and maximize lab space while decreasing test variability and the need for subsequent investigations. Once the deck is fully loaded, no supervision is required. The Nexus™delivers error-free, high-throughput LAL testing in a low-maintenance, flexible, high-precision package.

Features:

TEST PROCEDURE:

  • Place reagents, accessories and bar-coded samples on the deck.
  • The Nexus™ scans the barcodes to retrieve product information.
  • Samples are diluted as needed.
  • The gripper arm loads the MCS™ with cartridges.
  • EndoScan-V™ software is engaged to initiate testing.
  • Upon completion, the gripper arm removes each cartridge and places it in the disposal tray.
  • Test results are tracked using EndoScan-V™ and can be printed or sent to LIMS for further analysis.
 
Advantages:
  • Ramps up efficiency, testing 48-60 samples per run
  • Automates endotoxin testing, freeing up technicians for value-added tasks
  • Uses FDA-licensed PTS™ cartridges
  • Reduces bacterial endotoxin test variability
  • Tracks and trends results using EndoScan-V™ software
  • Enhances data management with bar coding technology
  • Can be utilized for central lab water testing and product testing


ENDOSAFE®-PTS™ GLUCAN ASSAY

We understand that you need to ensure that your products are as free of contaminants as possible. Charles River is proud to offer the Endosafe®-PTS™ glucan assay, a rapid, in-process test designed for investigational purposes to validate that your yeast-derived products are clear of (1,3)-ß-D glucans.

(1,3)-ß-D glucan molecules can be found in the cell walls of most yeasts and molds and can induce inflammatory responses. These glucans contaminate cell culture fluid, yeast protein production, air quality samples, and cellulose filter preparations. Glucans are known to cause false positive results in LAL assays, triggering investigations.

Charles River’s new PTS™ glucan assay allows you to quickly and easily quantify these glucans, leading to better process monitoring and faster out-of-specification (OOS) resolutions. The Charles River glucan cartridges have a sensitivity range of 10-1,000 pg/mL, yield results in less than 30 minutes, and can be run on the same Charles River instrument that is used for PTS™ endotoxin detection or PTS™ Gram ID.

This new product offering is in addition to the glucan-specific buffer that we offer for those compounds that you know in advance have a strong possibility of being contaminated by glucans.